Abstract: This paper aims to propose a novel quality overall design approach for complex products. The core parameter design and scheme optimization in the perspective of quality competitiveness are deeply addressed. Integrating the fuzzy QFD approach and the grey relational decision-making model, this paper explores the uncertain analysis and multiple attribute decision-making problems for the quality overall design of complex products. The overall quality design of a civil aircraft is presented as a numerical example, and conclusions and future work are discussed.